TABLE 6.
Induction potential of azithromycin, telithromycin, and compounds 13 and 19 by triple-disk diffusion method
| Strain | Phenotype | Genotype | Induction potentiala |
|||
|---|---|---|---|---|---|---|
| AZM | TEL | Compound 13 | Compound 19 | |||
| S. pyogenes | iMLSb-C | erm(A) | ** | ° | ° | ° |
| S. pyogenes | iMLSb-B | erm(A) | ** | ° | ° | ° |
| S. pyogenes | iMLSb-A | erm(B) | ** | ** | ° | ° |
| S. aureus | iMLSb | erm(C) | ** | ° | ° | ° |
| S. aureus | iMLSb | erm(A) | ** | ° | ° | ° |
a
All compounds were tested by use of a 0.5-μg/disk. AZM, azithromycin; TEL, telithromycin; **, induction toward erm expression for clindamycin and rokitamycin resistance; °, no induction.