TABLE 1.
Demographic data, underlying diseases, and PPCs in the study population
| Characteristic | Value for patients (n = 48) |
|---|---|
| No. (%) female/no. (%) male | 21 (43.8)/27 (56.3) |
| Median (range) age (yr) | 60 (26–81) |
| Median (range) body mass index | 26.1 (18.2–44.6) |
| Median (range) wt (kg) | 73.5 (50–115) |
| No. (%) with underlying disease(s) | |
| Acute myeloid leukemia | 31 (64.6) |
| Myelodysplastic syndrome | 7 (14.6) |
| Acute lymphoblastic leukemia | 5 (10.4) |
| Other | 5 (10.4) |
| No. (%) undergoing high-dose chemotherapy | 44 (91.7) |
| No. (%) undergoing allogeneic HSCT | 12 (25) |
| No. (%) with GVHD (stage 3 or higher) | 4 (8.3) |
| Median (IQR) PPC (mg/liter) at: | |
| Pre-steady state | 0.49 (0.28–0.68) |
| Early steady state | 0.44 (<0.20–0.77) |
| Late steady state (n = 34) | 0.45 (<0.20–0.93) |
| No. (%) with risk factor(s) for low PPCs | |
| Oral mucositis (grade 3 or higher at pre-steady-state and steady-state PPCs) | 2 (4.2) |
| Severe diarrhea (at pre-steady-state PPC) | 7 (14.6) |
| Severe diarrhea (at early-steady-state PPC) | 4 (8.3) |
| Proton pump inhibitor (at pre-steady-state and steady-state PPCs) | 30 (62.5) |
| Nausea, no solid food intake (at pre-steady-state and steady-state PPCs) | 3 (6.3) |