TABLE 1.

Simulated antibiotic dosing regimens and corresponding drug concentrations

Drug(s)	Simulated dosing regimen	Concn (mg/liter)	Reference
Amikacin	15-20 mg/kg of body wt every 24 h	80	13
Cefepime	2 g every 8 h	200	14
Levofloxacin	750 mg every 24 h	8	15
Rifampin	600 mg every 12 h	2	16
Tigecycline	100 mg every 12 h	2	17
Meropenem	2 g every 8 h (infused over 3 h)	64	18
Polymyxin B	30,000 IU/kg/day or at least 1 MU every 12 h	2	19
Imipenem	1 g every 6 h (infused over 0.5 h)	32	20
Doripenem	1 g every 8 h (infused over 4 h)	13	21
Aztreonam	6 g every 24 h (infused over 24 h)	18	22
Piperacillin-tazobactam	4.5 g every 6 h (infused over 4 h)	75/15	23