Table 1.
Mean baseline hematological data and genetic results of 11 children with Hb S/DPunjab and eight children with Hb S-Korle-Bu.
| Id/Gender | Hemoglobin (g/dL) | Leukocytes (×109/L) | Platelets (×109/L) | Reticulocytes (%) | Hb F (%) | Hb S (%) | Hb D (%) | βS haplotype/α−3.7 thalb |
|---|---|---|---|---|---|---|---|---|
| Children with Hb S/DPunjab(n = 11) | ||||||||
| 1/F | 7.2 | 13.9 | 347.7 | 4.0 | 13 | 48 | 37 | CAR/− |
| 2/M | 7.9 | 16.1 | 431.8 | 14.7 | 13 | 45 | 39 | ATP/− |
| 3/F | 6.8 | 13.7 | 368.0 | 8.7 | 14 | 38 | 44 | BEN/− |
| 4/M | 6.8 | 18.0 | 552.0 | 7.5 | 4 | 44 | 37 | CAR/− |
| 5/F | 8.3 | 15.2 | 300.2 | 9.5 | 22 | 41 | 35 | BEN/− |
| 6/Ma | 8.6 | 11.2 | 335.0 | 3.9 | 23 | 33 | 40 | BEN/+ |
| 7/F | 9.5 | 12.6 | 353.8 | 3.2 | 16 | 47 | 39 | BEN/− |
| 8/Ma | 8.9 | 15.0 | 454.0 | 6.4 | 21 | 36 | 40 | BEN/− |
| 9/M | 8.4 | 13.6 | 432.2 | 10.3 | 10 | 40 | 46 | CAR/+ |
| 10/M | 6.2 | 13.3 | 308.8 | 8.7 | 16 | 39 | 35 | CAR/− |
| 11/M | 9.5 | 11.2 | 430.9 | 5.9 | 25 | 37 | 36 | BEN/− |
| Mean | 8.0 | 14.0 | 392.2 | 7.5 | 16.1 | 40.7 | 38.9 | |
| Children with Hb S-Korle-Bu (n = 8) | ||||||||
| 1/M | 11.7 | 12.2 | 397.3 | 1.8 | 6 | 58 | 34 | CAR/+ |
| 2/M | 12.8 | 10.8 | 366.9 | 1.2 | 9 | 45 | 45 | CAR/− |
| 3/M | 11.5 | 7.1 | 326.6 | 1.0 | 7 | 45 | 42 | CAR/− |
| 4/F | 12.8 | 7.7 | 257.0 | 1.1 | 6 | 59 | 33 | BEN/− |
| 5/F | 13.2 | 10.1 | 275.6 | 0.4 | 9 | 41 | 48 | CAR/+ |
| 6/M | 12.3 | 11.4 | 331.7 | 0.6 | 6 | 39 | 52 | CAR/− |
| 7/M | 12.0 | 14.3 | 407.9 | 1.3 | 4 | 50 | 44 | CAR/− |
| 8/M | 11.8 | 10.5 | 266.3 | 0.8 | 8 | 39 | 50 | CAR/− |
| Mean | 12.3 | 10.5 | 328.7 | 1.0 | 6.9 | 47.0 | 43.5 | |
a
Brothers.
b
Co-inheritance (+ or −) of the alpha-thalassemia gene −α3.7 (−α3.7/αα).