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Schematic representation of antibacterial fluoroquinolone moxifloxacin 12 as part of the ternary complex (“cleavable complex”) with bacterial gyrase (GyrA/GyrB) or topo IV (ParC/ParE) and DNA. Moxifloxacin and other fluoroquinolones make interactions with both enzyme subunits, as well as p-stacking interactions with the DNA base pairs. A strand break between two base pairs, mediated by a topoisomerase catalytic tyrosine, is not shown.
