Table 16. Banyu eukaryotic biochemical and cellular SAR at quinolone N-1, C-5, C-7 and C-8 positions. Etoposide 14 was used as control.

Compound	R7	R8	R5	R1	Induction of DNA cleavable complex (T/C)a	L1210 cells CC50 (μg/ml)
115		F	-NH2		17.3	0.006
116 (-)-BO2367		F	H		15.3	0.012
117		-OCH3	H		14.3	0.026
118		F	H		10.0	0.17
119		F	H		8.6	0.30
120		H	H		6.7	0.50
121		F	H		6.7	1.1
122		H	H		1.8	1.7
123		F	H		1.5	4.0
16 8-F-ciprofloxacin		F	H		1.4	30