Table 21. Dainippon SAR showing the effect of variation of the quinolone C-7 substituent on eukaryotic cytotoxicity.

R7
P388 cells CC50 (μg/ml)a
Compound #
0.01	0.07	0.008	0.02
148	156	vosaroxin; 11	157
0.06	0.08	0.02	>10
158	159	160	161
>10	>1	6.33	7.37
162	163	164	165
Etoposide (14) = 0.01 (μg/ml)
Doxorubicin (13) = 0.004 (μg/ml)

^aMurine lymphocytic leukemia cell line