. 2016 Feb;23(6):520–577. doi: 10.2174/0929867323666151223095839

Table 22. Dainippon SAR for the C-3 position of N-1 2-thiazole quinolones: biochemical prokaryotic and eukaryotic IC₅₀ values and cytotoxicity in a P388 murine cell line.

Scaffold	Compound	R3	Antibacterial activity MIC (μg/ml)		Cytotoxicity CC₅₀ (μg/ml)^a
Scaffold	Compound	R3	*E. coli* NIHJ JC-2	*S. aureus* 209 JC-1	murine P388^b
	130	-CO₂H	0.025	0.39	0.02
	169	-H	12.5	12.5	0.18
	170	-CONH₂	>100	>100	0.27
	11	-CO₂H vosaroxin	1.56	3.13	0.01
	171	-CH₂OH	>100	25	0.06

^a Concentration that reduces cell viability by 50%; ^bmurine lymphocytic leukaemia cell line.

Table 22. Dainippon SAR for the C-3 position of N-1 2-thiazole quinolones: biochemical prokaryotic and eukaryotic IC50 values and cytotoxicity in a P388 murine cell line.