Table 8. In vivo activity of Abbott quinobenoxazine 56 against human tumor xenographs.
Tumor | Treatment route and schedule | Dose (mg/kg) | Best % TWIa | Cures (%) |
---|---|---|---|---|
CX-1 colon |
i.p. QD D2-11 | 20 | 79 | * |
MBA 9812 mammary | i.p. QD D2-11 | 20 | 76 | * |
LX-1 lung |
i.p. QD D2-11 | 20 | 43 | * |
MX-1 mammary | i.v. Q4Dx3 | 40 | 84 | 30 |
HT29 colon |
i.v. Q4Dx3 | 40 | 21 | * |
aTumor weight inhibition; *data not reported.