A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial Quinolone

. 2016 Feb;23(6):520–577. doi: 10.2174/0929867323666151223095839

Compound	R6	R7	X	MRSA^a MIC (µg/ml)	Hep2 cells^b CC₅₀ (µg/ml)^c [topo II EC₂ (µg/ml)]^c,d

102 gemifloxacin	F		N	2	18 [>59]

^aMethicillin resistant S. aureus (methicillin- and quinolone-resistant, vancomycin intermediate-resistant); ^bHep2 = human laryngeal carcinoma cell line; CC₅₀ = concentration of drug lethal to 50% of cells; 72h incubation with drug; ^cvalues originally reported as μM were converted to μg/ml for this table; ^dEC₂ = concentration of drug required to enhance enzyme-mediated cleavage of double-stranded DNA twofold.