Table 2.

Vinblastine delivery systems.

Material	Formula	Size	Treatment	Reference
Thymidine conjugate	vinblastine-thymidine (Covalent Bond)	Molecular level	K562, HT29, and MCF7 cell lines	[19]
Folic acid and folate	desacetylvinblastine monohydrazide attached to a hydrophilic folic acid-peptide compound(EC145) (Covalent Bond)	Molecular level	novel synthesis study and the clinical pharmacokinetics and exposure-toxicity relationship study	[77, 79]
	vinblastine-folate by carbohydrate-based synthetic approach(EC0905) (Covalent Bond)	Molecular level	novel synthesis study and invasive urothelial carcinoma in dogs	[80-82]
	vinblastine sulfate-loaded folate-conjugated bovine serumalbumin nanoparticles	~150 nm	novel synthesis study	[83]
PLGA	vinblastine encapsulated in PLGA microspheres	46 μm	pharmacokinetics study	[84]
Liposome	anti-HER2 immunoliposomal vinblastine	99.5 nm	SKBR-3 and BT474-M2 in vitro and BT474-M2 xenografts in mice	[85]
	magnetic cationic liposomes packaged vinblastine	105-267 nm	B16-F10 in vitro and in mice	[74, 78]
	anionic liposomes (DPPC and DPPG with cholesterol)	-	six cell lines tested	[86]
	new liposome formulations (wheat germ lipids)	-	against nine human leukemic cell lines	[87]
	multi-lamellar vesicle-liposomes	-	UV-2237M murine fibrosarcoma and its Adriamycin (ADR)-selected multidrug resistant (MDR) variants.	[88]