Table IV.

Number of patients with the four polymorphisms and their association with prediabetes and type 2 diabetes, based on three genetic models, and stratified by gender.

						Additive model		Dominant model		Recessive model
Variable	Wild-type homozygote	Heterozygote	Variant homozygote	Major allele	Minor allele	OR (95% CI)b	P	OR (95% CI)b	P	OR (95% CI)b	P	HWE
IGF2BP2 rs11705701
Female
Controls	173	104	7	450	118	Reference		Reference		Reference		0.058
Prediabetes	137	80	20	354	120	0.79 (0.58–1.07)	0.146	0.26 (0.10–0.67)	0.005a	0.91 (0.63–1.33)	0.656
Type 2 diabetes	141	80	9	362	98	1.01 (0.72–1.41)	0.947	0.62 (0.21–1.81)	0.383	1.07 (0.73–1.57)	0.705
Male
Controls	187	86	10	460	106	Reference		Reference		Reference		0.972
Prediabetes	131	82	11	344	104	0.79 (0.57–1.09)	0.158	0.77 (0.31–1.93)	0.585	0.75 (0.51–1.10)	0.148
Type 2 diabetes	139	82	10	360	102	0.83 (0.60–1.14)	0.265	0.72 (0.28–1.84)	0.506	0.82 (0.56–1.19)	0.305
IRS1 rs7578326
Female
Controls	202	67	10	471	87	Reference		Reference		Reference		0.142
Prediabetes	185	48	6	418	60	0.78 (0.54–1.12)	0.184	0.74 (0.48–1.14)	0.174	0.74 (0.24–2.27)	0.602
Type 2 diabetes	182	58	5	422	68	0.93 (0.65–1.33)	0.719	0.96 (0.63–1.46)	0.875	0.66 (0.20–2.10)	0.487
Male
Controls	199	67	5	465	77	Reference		Reference		Reference		0.817
Prediabetes	164	63	2	391	67	1.06 (0.72–1.54)	0.765	1.06 (0.72–1.54)	0.766	0.53 (0.10–2.85)	0.466
Type 2 diabetes	181	60	1	422	62	0.86 (0.59–1.27)	0.474	0.91 (0.60–1.37)	0.654	0.24 (0.02–2.21)	0.214
GIPR rs10423928
Female
Controls	186	88	6	460	100	Reference		Reference		Reference		0.238
Prediabetes	169	63	7	401	77	0.96 (0.68–1.36)	0.821	0.91 (0.61–1.35)	0.653	1.40 (0.44–4.44)	0.565
Type 2 diabetes	166	69	10	401	89	1.02 (0.73–1.43)	0.883	0.96 (0.65–1.41)	0.846	1.75 (0.58–5.30)	0.316
Male
Controls	176	83	14	435	111	Reference		Reference		Reference		0.205
Prediabetes	140	83	7	363	97	1.00 (0.73–1.38)	0.962	1.09 (0.75–1.60)	0.628	0.60 (.23–1.56)	0.304
Type 2 diabetes	152	82	8	386	98	1.01 (0.73–1.39)	0.925	1.07 (0.73–1.56)	0.703	0.73 (0.29–1.86)	0.514
TCF7L2 rs12255372
Female
Controls	97	148	37	342	222	Reference		Reference		Reference		0.116
Prediabetes	99	107	31	305	169	0.83 (0.63–1.10)	0.209	0.74 (0.51–1.08)	0.114	0.93 (0.53–1.60)	0.797
Type 2 diabetes	90	102	38	282	178	0.95 (0.72–1.25)	0.736	0.80 (0.54–1.18)	0.276	1.25 (0.74–2.12)	0.395
Male
Controls	111	135	35	357	205	Reference		Reference		Reference		0.35
Prediabetes	95	96	33	286	162	0.93 (0.71–1.22)	0.645	0.86 (0.59–1.25)	0.445	1.04 (0.61–1.78)	0.87
Type 2 diabetes	105	92	33	302	158	0.86 (0.66–1.12)	0.266	0.75 (0.52–1.09)	0.142	0.97 (0.56–1.65)	0.919

^aStatistically significant results.

^bAdjusted for age and body mass index. OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium; IGF2BP2, insulin-like growth factor 2 mRNA-binding protein 2; IRS1, insulin receptor substrate 1; GIPR, gastric inhibitory polypeptide receptor; TCF7L2, transcription factor 7-like 2.