Table V.

Gene-gene and gene-environment interaction analysis by generalized multi-factor dimensionality reduction.

Model	Testing balance accuracy	Sign test	Cross-validation consistency
Prediabetes vs. controls
Gene-environment interactions
BMI	0.602	0.001	10/10
BMI, rs7578326	0.608	0.001	6/10
BMI, rs11705701, rs7578326	0.596	0.001	6/10
Age, BMI, rs11705701, rs7578326	0.605	0.001	9/10
Gender, BMI, rs11705701, rs12255372, rs7578326	0.559	0.001	10/10
Gender, age, BMI, rs11705701, rs12255372, rs7578326	0.603	0.001	10/10
Gender, age, BMI, rs11705701, rs12255372, rs7578326, rs10423928	0.564	0.015	10/10
Gene-gene interactions
rs12255372	0.509	0.178	7/10
rs11705701, rs12255372	0.494	0.623	6/10
rs11705701, rs12255372, rs7578326	0.515	0.175	8/10
rs11705701, rs12255372, rs7578326, rs10423928	0.523	0.054	10/10
Type 2 diabetes vs. controls
Gene-environment interactions
Age	0.591	0.001	10/10
Age, rs11705701	0.595	0.001	5/10
Age, BMI, rs12255372	0.613	0.001	9/10
Age, BMI, rs12255372, rs10423928	0.604	0.001	9/10
Age, BMI, rs11705701, rs12255372, rs10423928	0.582	0.001	8/10
Gender, age, BMI, rs11705701, rs12255372, rs10423928	0.583	0.001	7/10
Gender, age, BMI, rs11705701, rs12255372, rs7578326, rs10423928	0.554	0.001	10/10
Gene-gene interactions
rs12255372	0.532	0.054	10/10
rs12255372, rs10423928	0.543	0.015	9/10
rs12255372, rs7578326, rs10423928	0.515	0.054	4/10
rs11705701, rs12255372, rs7578326, rs10423928	0.548	0.001	10/10

BMI, body mass index.