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. 2016 Mar;23(7):686–700. doi: 10.2174/0929867323666160122115057

Table 1.

Summary of the effects of 5-HT1A agonists on models or patients of Parkinson's disease

5-HT1A agonist Effectiveness Targeted Cell Reference
Bay x 3702 neuroprotection astrocyte [147]
BAY 639044 neuroprotection neuron [159]
R-UH-301 neuroprotection neuron [160]
8-OH-DPAT neuroprotection neuron [160]
astrocyte [18]
eltoprazine dyskinesia neuron [167]
unknown [140, 141]
N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate dyskinesia neuron [142]
8-OH-DPAT dyskinesia unknown [138]
improvement of motor fluctuation unknown [139]
anxiolytic effects neuron [162]
antidepressant-like effects neuron [163]
F15599 dyskinesia neuron [164]
F13714 dyskinesia neuron [165]
F13640 dyskinesia unknown [166]
anxiolytic effects unknown [166]
antidepressant-like effects unknown [166]
buspirone dyskinesia neuron [161]