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. 2016 Aug 19;11:4037–4050. doi: 10.2147/IJN.S108545

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© 2016 Pan et al. This work is published and licensed by Dove Medical Press Limited

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In vitro skin percutaneous studies of FK506 from different vehicles.

Notes: Data represent mean ± SD, n=4 per group. ^*Significantly different (P<0.05) in comparison with FK506 aqueous suspension. ^**Significantly different (P<0.05) in comparison with Protopic, 0.1%, w/w. ^***Significantly different (P<0.05) in comparison with FK506–NPs. ^****Significantly different (P<0.05) in comparison with FK506–NIC solution. The concentration of FK506 in each formulation was 1 mg/mL.

Abbreviations: FK506, tacrolimus; FK506–HA–Chol–NPs, tacrolimus-loaded hyaluronic acid–cholesterol nanoparticles; FK506–HA–Chol–NPs–NIC, tacrolimus-loaded hyaluronic acid–cholesterol nanoparticles containing nicotinamide; FK506–NIC complex, tacrolimus–nicotinamide complex; FK506–NPs, tacrolimus–nanoparticles complex; h, hours; SD, standard deviation.