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. 2016 Jul 15;12(3):1745–1752. doi: 10.3892/ol.2016.4865

Figure 3.

Figure 3.

(A) LL-37 induces migration in A431 cells. Serum-starved A431 were treated with LL-37 at 0.05, 0.5 and 5 µg/ml of LL-37 for 12 h, and the cell migration was analysed. (B) LL-37 induces invasion of A431 cells. Serum-starved A431 cells were treated with LL-37 at 0.05, 0.5 and 5 µg/ml of LL-37 for 24 h, and the cell invasion was analysed. Magnification, ×200. The results from three random fields are shown and presented as the mean ± standard deviation. (C) LL-37 promotes the upregulation of dbpA mRNA in A431 cells. Time effect: A431 cells were stimulated with 0.5 µg/ml LL-37 for the specified durations. Dose effects: A431 cells were stimulated with the specified doses of LL-37 for 24 h. DbpA mRNA levels were determined by quantitative polymerase chain reaction. The figure shows the ratio of dbpA mRNA/β-actin mRNA. *P<0.05 vs. control, 0 h or 0 µg/ml. siRNA, small interfering RNA; dbpA, DNA-binding protein A.