Table III.
C677T MTHFR and G20210A FII polymorphism frequencies and genetic distribution among the cases and controls.
| Genes | Genotypes | Cases, n (%) (n=100) | Controls, n (%) (n=182) | OR (95% CI) | P-value (P<0.05) |
|---|---|---|---|---|---|
| MTHFR | CC | 38 (38.0) | 95 (52.2) | Ref | |
| CT | 52 (52.0) | 76 (41.8) | 1.71 (1.02–2.84) | 0.61 | |
| TT | 10 (10.0) | 11 (6.0) | 2.27 (0.88–5.82) | 0.64 | |
| C | 128 (64.0) | 171 (73.1) | Ref | ||
| T | 72 (36.0) | 87 (26.9) | 1.35 (0.89–2.03) | 0.75 | |
| FII | GG | 31 (31.0) | 172 (94.5) | Ref | |
| GA | 59 (59.0) | 10 (5.5) | 32.73 (15.11–69.71) | <0.001a | |
| AA | 10 (10.0) | 0 (0.0) | 115 (1.75–7332) | 0.003a | |
| G | 121 (60.5) | 182 (97.3) | Ref | ||
| A | 79 (39.5) | 0 (2.7) | 238.83 (4.48–12581.7) | <0.001a |
a
P<0.05. MTHFR, 5,10-methylenetetrahydrofolate reductase; FII, factor II prothrombin; OR, odds ratio; CI, confidence interval.