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. 2016 Jun 27;12(3):1251–1262. doi: 10.3892/etm.2016.3485

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Copyright: © Jung et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Histological profiles of the femur of the (A and B) sham, (C and D) ovariectomized control and (E and F) alendronate-treated groups, and the (G and H) 31.25, (I and J) 62.5 and (K and L) 125 mg/kg Polycan-treated groups. Polycan inhibited the ovariectomy-induced reduction in trabecular bone mass and cortical bone thickness in a dose-dependent manner. Conversely, alendronate attenuated the ovariectomy-induced reduction in trabecular bone mass only. A, C, E, G, I and K display epiphyseal plate-trabecular bone regions (magnification, ×25); B, D, F, H, J, and L display cortical bone regions (magnification, ×50). Arrows represent the cortical thickness. All sections were stained with hematoxylin and eosin.