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. 2016 Jun 27;12(3):1251–1262. doi: 10.3892/etm.2016.3485

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Copyright: © Jung et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Fluorescent histological profiles of the femur of the (A and B) sham, (C and D) ovariectomized (OVX) control and (E and F) alendronate-treated groups, and the (G and H) 31.25, (I and J) 62.5 and (K and L) 125 mg/kg Polycan-treated groups. The mineral apposition rate (MAR) was markedly increased in the trabecular and cortical bone regions of the femur in the Polycan-treated rats, in a dose-dependent manner, as compared with the OVX control group. Conversely, the MAR was markedly decreased in both bone regions of the femur in the alendronate-treated rats, as compared with the OVX control group. A, C, E, G, I and K display trabecular bone regions (magnification, ×200); B, D, F, H, J and L display cortical bone regions (magnification, ×200). Arrows indicate the tetracycline and calcein labeled lines. The distant between the arrows represents the MAR over a 10-day period.