Table IV.
Polycan-treated groups | ||||||
---|---|---|---|---|---|---|
Bone | Sham control | OVX control | Alendronate | 31.25 mg/kg | 62.5 mg/kg | 125 mg/kg |
Femur | ||||||
Ca mg/g bone | 170.86±13.75 | 95.82±17.78a | 120.95±12.40a,b | 106.05±14.02c | 125.12±9.03a,b | 138.07±16.11a,b |
P mg/g bone | 98.71±7.56 | 57.29±11.04a | 73.60±13.18a,b | 63.19±9.20c | 76.48±11.47a,d | 83.30±10.28c,d |
Ca/P ratio | 1.74±0.16 | 1.70±0.34 | 1.69±0.34 | 1.70±0.28 | 1.67±0.29 | 1.68±0.29 |
Tibia | ||||||
Ca mg/g bone | 196.13±9.74 | 103.82±15.02a | 133.37±21.61a,d | 110.14±14.66c | 128.77±10.45a,d | 140.72±15.00a,d |
P mg/g bone | 99.66±11.83 | 52.67±7.66a | 67.93±7.47a,d | 55.54±6.04c | 67.11±6.52a,d | 70.00±7.12a,d |
Ca/P ratio | 1.99±0.22 | 1.99±0.31 | 1.99±0.42 | 2.00±0.31 | 1.93±0.17 | 2.03±0.28 |
L4 | ||||||
Ca mg/g bone | 210.14±8.35a | 124.41±12.48a | 138.50±9.19a | 138.10±13.87c | 146.84±16.78a,b | 155.79±11.09a,d |
P mg/g bone | 113.50±13.77a | 66.91±8.53a | 74.12±7.24a | 75.61±12.46c | 78.77±10.05a,b | 83.25±6.81a,d |
Ca/P ratio | 1.87±0.23 | 1.90±0.45 | 1.88±0.20 | 1.87±0.38 | 1.88±0.23 | 1.88±0.16 |
Data are presented as the mean ± standard deviation of 8 rats.
P<0.01
P<0.05 vs. sham control group.
P<0.05
P<0.01 vs. OVX control group. OVX, ovariectomized; L4, 4th lumbar vertebrae.