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. 2016 Jun 27;12(3):1251–1262. doi: 10.3892/etm.2016.3485

Table V.

Alterations in BMD and FL in the rat femur, tibia and L₄ verterae.

				Polycan-treated groups

Bone	Sham control	OVX control	Alendronate	31.25 mg/kg	62.5 mg/kg	125 mg/kg
Femur
Epiphyseal BMD	0.378±0.040	0.213±0.032^a	0.513±0.107^a,b	0.253±0.026^a,c	0.286±0.030^a,b	0.293±0.021^a,b
Mid-shaft BMD	0.336±0.036	0.189±0.025^a	0.224±0.027^a,c	0.228±0.032^a,c	0.251±0.037^a,b	0.265±0.029^a,b
FL	119.03±8.68	70.48±11.39^a	83.50±7.70^a,c	78.03±6.39^a	86.30±6.08^b,c	88.33±10.02^a,c
Tibia
Epiphyseal BMD	0.305±0.023	0.199±0.017^a	0.385±0.066^a,b	0.221±0.034^a	0.249±0.026^a,b	0.268±0.046^b
Mid-shaft BMD	0.291±0.015	0.179±0.023^a	0.195±0.024^a	0.209±0.020^a,c	0.224±0.025^a,b	0.243±0.042^a,b
FL	79.61±2.44	50.96±6.27^a	55.69±11.18^a	57.25±4.78^a	62.06±3.52^a,b	63.41±5.05^a,b
L₄
Epiphyseal BMD	0.338±0.034	0.225±0.023^a	0.255±0.030^a,c	0.249±0.026^a	0.258±0.025^a,c	0.293±0.015^a,b
Mid-shaft BMD	0.305±0.021	0.186±0.028^a	0.199±0.022^a	0.205±0.016^a	0.238±0.019^a,b	0.256±0.033^a,b
FL	66.20±5.35	42.20±8.25^a	50.06±11.14^a	48.93±5.85^a	50.60±6.03^a,c	57.08±6.25^b,d

Data are presented as the mean ± standard deviation of 8 rats.

^a

P<0.01

^d

P<0.05 vs. sham control group.

^b

P<0.01

^c

P<0.05 vs. OVX control group. OVX, ovariectomized; L₄, 4th lumbar vertebrae; BMD, bone mineral density; FL, failure load.