. 2016 Jun 27;12(3):1251–1262. doi: 10.3892/etm.2016.3485

Table VI.

Alterations in femur histomorphometry.

				Polycan treated groups

Indices	Sham control	OVX control	Alendronate	31.25 mg/kg	62.5 mg/kg	125 mg/kg
Bone mass and structure
Tb.Ar	42.66±5.11	16.48±4.03^a	62.49±4.93^a,b	20.62±3.78^a	23.90±3.28^a,b	25.91±4.99^a,b
N.Tb	20.88±3.36	6.38±1.85^a	40.38±8.18^a,b	8.00±1.69^a	10.50±1.51^a,b	11.50±2.00^a,b
Tb.Pm	1,895.31±306.08	949.62±152.97^a	1,265.30±196.52^a,b	1,069.78±145.09^a	1,308.83±321.95^a,c	1,326.88±271.85^a,b
Tb.Wi	112.70±10.97	75.33±10.21^a	76.35±13.93^a	100.92±25.73^c	103.86±20.33^b	122.20±21.61^b
Ct.Wi	454.86±67.54	210.30±26.04^a	200.93±27.21^a	329.64±79.46^a,c	367.91±36.69^a,b	370.46±83.22^b
Bone resorption
N.Oc	13.00±1.41	27.00±3.63^a	35.63±10.65^a	27.13±3.52^a	25.25±3.49^a	20.25±2.25^a,b
Oc/BS	4.72±0.79	10.96±1.22^a	9.12±1.18^a,c	10.62±1.53^a	10.54±0.90^a	9.13±1.15^a,c
Trabecular bone formation
MAR	0.95±0.13	1.54±0.11^a	0.71±0.08^a,b	1.67±0.12^a,b	1.82±0.20^a,c	1.85±0.23^a,b
sL.Pm	7.17±1.22	13.21±1.56^a	4.29±0.38^a,b	14.24±1.04^a	15.87±2.36^a,c	16.12±2.44^a,c
dL.Pm	14.39±3.14	24.73±3.92^a	7.96±0.97^a,b	27.37±3.14^a	29.41±3.23^a,c	31.25±4.49^a,b
Md.Pm	17.97±3.64	31.33±4.53^a	10.11±1.14^a,b	34.50±3.60^a	37.35±4.20^a,c	39.31±5.58^a,b
BFR/BS	0.173±0.054	0.484±0.091^a	0.072±0.013^a,b	0.579±0.094^a	0.685±0.138^a,c	0.738±0.208^a,b
Cortical bone formation
MAR	1.17±0.13	1.78±0.14^a	0.76±0.09^a,b	1.82±0.16^a	1.98±0.08^a,b	2.06±0.17^a,b
sL.Pm	8.22±1.57	15.27±1.70^a	4.21±0.96^a,b	15.00±1.95^a	17.27±1.25^a,c	17.94±1.25^a,b
dL.Pm	15.54±3.01	30.71±2.10^a	7.76±1.87^a,b	29.91±2.86^a	34.18±2.72^a,c	35.54±2.94^a,b
Md.Pm	19.65±3.78	38.34±2.72^a	9.86±2.32^a,b	37.41±3.82^a	42.82±3.28^a,c	44.51±3.46^a,b
BFR/BS	0.233±0.068	0.684±0.093^a	0.076±0.026^a,b	0.685±0.126^a	0.850±0.091^a,b	0.922±0.146^a,b

Data are presented as the mean ± standard deviation of 8 rats.

P<0.01 vs. sham control group.

P<0.01

P<0.05 vs. OVX control group. OVX, ovariectomy; Tb.Ar, trabecular bone volume (%); N.Tb, trabecular bone number; Tb.Pm, trabecular bone length (mm), Tb.Wi, trabecular bone thickness (µm); Ct.Wi, cortical bone thickness (µm); N.Oc, osteoclast cell number (no.); Oc/BS, osteoclast cell surface/bone surface (%); MAR, mineral appositional rate (µm/day); sL.Pm, single labeled surface (%); dL.Pm, double labeled surface (%); Md.Pm, mineralizing surface (%); BFR/BS, bone forming rate/bone surface referent (µm³/µm²/day).