Table VII.
Alterations in tibia histomorphometry.
| Polycan-treated groups | ||||||
|---|---|---|---|---|---|---|
| Indices | Sham control | OVX control | Alendronate | 31.25 mg/kg | 62.5 mg/kg | 125 mg/kg |
| Bone mass and structure | ||||||
| Tb.Ar | 47.45±6.33 | 13.04±3.79b | 64.45±6.47b,d | 22.43±4.27b,d | 25.38±3.85b,d | 27.22±3.29b,d |
| N.Tb | 20.38±2.20 | 4.63±1.19b | 39.50±8.12b,d | 9.25±1.04b,d | 11.50±0.76b,d | 12.00±1.07b,d |
| Tb.Pm | 1,508.45±110.35 | 851.03±94.96b | 1,231.12±169.41b,d | 1,099.82±131.94b,d | 1,291.69±234.41a,d | 1,451.76±119.05d |
| Tb.Wi | 108.16±16.31 | 77.43±12.37b | 61.87±11.66b,c | 96.88±18.12c | 108.29±11.00d | 119.10±7.84a,d |
| Ct.Wi | 431.64±34.60 | 234.08±23.94b | 233.95±29.48b | 275.77±31.73b,c | 310.00±54.57b,d | 355.05±37.31b,c |
| Bone resorption | ||||||
| N.Oc | 14.88±2.70 | 32.25±6.43b | 35.88±8.82b | 32.63±6.30b | 27.75±6.18b | 21.00±2.56b,d |
| Oc/BS | 4.99±0.69 | 13.40±1.31b | 10.49±1.28b,d | 13.10±1.38b | 10.32±1.12b,d | 9.77±1.19b,d |
| Trabecular bone formation | ||||||
| MAR | 0.94±0.12 | 1.25±0.14b | 0.74±0.04b,d | 1.31±0.07b | 1.39±0.08b,d | 1.59±0.12b,d |
| sL.Pm | 6.01±1.38 | 9.77±0.91b | 4.20±0.53b,d | 10.13±0.61b | 11.08±1.16b,c | 13.32±1.71b,d |
| dL.Pm | 11.04±2.62 | 18.57±2.34b | 7.80±1.59a,d | 19.24±1.97b | 21.19±2.40b | 25.94±3.70b,d |
| Md.Pm | 14.04±3.26 | 23.46±2.74b | 9.90±1.82a,d | 24.31±2.15b | 26.73±2.95b,c | 32.61±4.52b,d |
| BFR/BS | 0.135±0.046 | 0.294±0.058b | 0.074±0.016b,d | 0.318±0.041b | 0.372±0.057b,c | 0.552±0.108b,d |
| Cortical bone formation | ||||||
| MAR | 1.12±0.10 | 1.39±0.06b | 1.06±0.15d | 1.44±0.11b | 1.82±0.15b,d | 1.89±0.16b,d |
| sL.Pm | 7.88±0.80 | 11.06±1.17b | 7.76±1.42d | 11.14±1.48b | 15.09±1.69b,d | 15.80±1.82b,d |
| dL.Pm | 15.45±1.17 | 22.02±2.71b | 13.57±2.99d | 21.77±2.85b | 29.87±3.37b,d | 31.46±3.53b,d |
| Md.Pm | 19.39±1.55 | 27.55±3.28b | 17.44±3.66d | 27.34±3.54b | 37.42±4.21b,d | 39.36±4.44b,d |
| BFR/BS | 0.218±0.035 | 0.384±0.062b | 0.188±0.060d | 0.397±0.079b | 0.686±0.137b,d | 0.749±0.146b,d |
Data are presented as the mean ± standard deviation of 8 rats.
a
P<0.01
b
P<0.05, vs. sham control group.
c
P<0.01
d
P<0.05, vs. OVX control group. OVX, ovariectomy; Tb.Ar, trabecular bone volume (%); N.Tb, trabecular bone number; Tb.Pm, trabecular bone length (mm), Tb.Wi, trabecular bone thickness (µm); Ct.Wi, cortical bone thickness (µm); N.Oc, osteoclast cell number (no.); Oc/BS, osteoclast cell surface/bone surface (%); MAR, mineral appositional rate (µm/day); sL.Pm, single labeled surface (%); dL.Pm, double labeled surface (%); Md.Pm, mineralizing surface (%); BFR/BS, bone forming rate/bone surface referent (µm3/µm2/day).