. 2016 Jun 27;12(3):1251–1262. doi: 10.3892/etm.2016.3485

Table VIII.

Alterations in L₅ histomorphometry.

				Polycan treated groups

Indices	Sham control	OVX control	Alendronate	31.25 mg/kg	62.5 mg/kg	125 mg/kg
Bone mass and structure
Tb.Ar	40.20±6.73	20.30±4.07^a	51.66±9.66^a,c	23.78±2.71^a,d	27.18±3.42^a,c	30.31±2.44^a,c
N.Tb	20.38±4.66	9.13±1.36^a	28.00±4.34^b,c	10.75±0.89^a,d	11.88±0.64^a,c	12.00±1.69^a,c
Tb.Pm	1,597.39±311.46	900.66±158.97^a	1,212.59±194.92^b,d	1,239.49±239.10^b,c	1,409.77±369.62^c	1,538.50±211.31^c
Tb.Wi	130.11±18.75	86.26±10.63^a	69.03±5.64^a,d	114.09±13.49^c	124.98±26.79^c	130.69±24.9^c
Ct.Wi	221.60±28.28	120.44±34.25^a	123.35±33.39^a	154.38±23.34^a,d	164.45±26.12^a,c	166.47±45.03^a,d
Bone resorption
N.Oc	11.63±1.41	23.00±2.14^a	30.75±5.55^a,c	23.63±2.20^a	20.75±1.58^a,d	19.63±2.62^a,d
Oc/BS	3.90±0.68	12.09±0.86^a	9.48±1.01^a,c	11.61±1.30^a	10.07±1.23^a,c	9.57±0.92^a,c
Trabecular bone formation
MAR	0.83±0.12	1.20±0.09^a	0.77±0.10^c	1.31±0.10^a	1.33±0.15^a	1.43±0.08^a,c
sL.Pm	4.91±1.35	9.79±0.92^a	4.07±0.59^c	10.26±1.05^a	11.22±1.34^a,d	11.71±1.34^a,c
dL.Pm	9.23±2.21	18.81±2.68^a	7.92±1.09^c	19.75±2.33^a	22.36±2.21^a,d	22.99±2.34^a,c
Md.Pm	11.69±2.86	23.71±3.03^a	9.95±1.33^c	24.88±2.66^a	27.97±2.79^a,d	28.85±2.97^a,c
BFR/BS	0.099±0.036	0.287±0.055^a	0.078±0.017^c	0.327±0.055^a	0.374±0.074^a,d	0.413±0.063^b,c
Cortical bone formation
MAR	1.01±0.12	1.37±0.13^a	0.84±0.13^b,c	1.62±0.20^a,c	1.78±0.14^a,c	1.87±0.10^a,c
sL.Pm	6.96±1.30	10.76±0.75^a	5.87±1.52^c	13.04±2.56^a,d	14.62±1.35^a,c	12.79±1.45^a,c
dL.Pm	13.45±2.63	22.00±2.32^a	10.57±2.39^b,c	25.83±5.52^a	28.66±2.53^a,c	31.79±2.26^a,c
Md.Pm	16.93±3.25	27.39±2.61^a	13.50±3.15^c	32.37±6.79^a	35.97±2.80^a,c	39.68±2.94^a,c
BFR/BS	0.174±0.054	0.375±0.051^a	0.117±0.043^b,c	0.536±0.188^a,d	0.640±0.081^a,c	0.743±0.095^b,c

Data are presented as the mean ± standard deviation of 8 rats.

P<0.01

P<0.05, vs. sham control group.

P<0.01

P<0.05, vs. OVX control group. OVX, ovariectomy; Tb.Ar, trabecular bone volume (%); N.Tb, trabecular bone number; Tb.Pm, trabecular bone length (mm), Tb.Wi, trabecular bone thickness (µm); Ct.Wi, cortical bone thickness (µm); N.Oc, osteoclast cell number (no.); Oc/BS, osteoclast cell surface/bone surface (%); MAR, mineral appositional rate (µm/day); sL.Pm, single labeled surface (%); dL.Pm, double labeled surface (%); Md.Pm, mineralizing surface (%); BFR/BS, bone forming rate/bone surface referent (µm³/µm²/day).