Table I.
Correlation of nuclear NICD in gastric cancer with clinicopathological factors, including patient and tumor characteristics (n=115).
| Characteristics | NICD-positive patients/total patients | P-value |
|---|---|---|
| Age at surgery (years) | 0.1315 | |
| ≤65 | 39/66 | |
| >65 | 22/49 | |
| Gender | 0.4953 | |
| Male | 41/74 | |
| Female | 20/41 | |
| Location | 0.9236 | |
| Upper | 15/27 | |
| Middle | 21/39 | |
| Lower | 25/49 | |
| Tumor status | 0.0069 | |
| T1 | 23/57 | |
| T2 | 9/15 | |
| T3 | 9/17 | |
| T4 | 20/26 | |
| T1 vs. T2-4 | 23/57 vs. 38/58 | |
| Lymph node status | 0.0118 | |
| N0 | 30/69 | |
| N-positive | 31/46 | |
| Pathological stage | 0.0160 | |
| I | 27/63 | |
| II | 13/21 | |
| III | 21/31 | |
| I vs. II–IV | 27/63 vs. 34/52 | |
| Histological differentiation | 0.0232 | |
| Differentiated | 38/82 | |
| Undifferentiated | 23/33 | |
| Lymphatic invasion | 0.1385 | |
| Negative | 20/45 | |
| Positive | 41/70 | |
| Blood vessel invasion | 0.0786 | |
| Negative | 25/56 | |
| Positive | 36/59 |
NICD, NOTCH1 intracellular cytoplasmic domain.