Table 2.

Multivariable Cox proportional regression of predictors of overall survival of trimodality eligible patients with locally advanced esophageal adenocarcinoma treated with chemoradiation followed by surgery or definitive chemoradiation (n=143)

Predictor	n	Univariate Cox Regressiona			Multivariable Cox Regressionb
		p-value	HR	95% CI	p-value	HR	95% CI
Agec	143	0.088	1.017	0.997–1.037	0.469	1.008	0.987—1.1029
Sex
Male	134		1.000
Female	9	0.698	1.179	0.513—2.708
Race/Ethnicity
White	129		1.000
Non-White	14	0.963	0.984	0.491—1.972
Comorbidity Score
0	97		1.000
≥1	46	0.273	1.282	0.822—2.001
Tumor Length	143	0.338	0.963	0.893—1.040
Tumor Grade
Well/Moderately Differentiated	52		1.000
Poorly Differentiated	91	0.005	2.028	1.242—3.310	0.005	2.041	1.235—3.373
CXRT Sequence
Chemo/XRT	63		1.000
Induction Chemotherapy → Chemo/XRT	80	0.702	0.919	0.597—1.415
XRT Dose
<50.4 Gy	45		1.000
50.4 Gy	98	0.238	1.317	0.834—2.080
Pre-Treatment Local SUV		0.984
≤6.8	29		1.000
6.8–10.1	38	0.700	1.128	0.611—2.083
10.1–15.8	34	0.893	1.045	0.547—1.998
≥15.8	37	0.900	1.041	0.553—1.963
missing	5	0.769	1.179	0.393—3.537
Post-Treatment Local SUV		0.051			0.097
<3.45	39		1.000
3.45–8.75	82	0.187	1.417	0.844—2.378	0.298	1.320	0.782—2.228
≥8.75	12	0.007	2.844	1.325—6.105	0.012	2.686	1.237—5.830
missing	10	0.139	1.923	0.808—4.577	0.453	1.432	0.560—3.663
Surgical Resection
No	29		1.000
Yes	114	0.014	0.539	0.329—0.881	0.020	0.504	0.283—0.899

NOTE: CXRT = chemoradiation; Chemo = chemotherapy; XRT = radiation; Gy = Gray; SUV = standard uptake value

^aAny variable with a univariate association of p<0.25 (bolded in table) was carried forward to multivariable analysis

^bFinal model of multivariable regression displayed in the table. Wald’s stepwise selection with p=0.10 was used as entry and removal probability until the final model for the data set was obtained.

^cFinal multivariable model age-adjusted