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. Author manuscript; available in PMC: 2016 Aug 25.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2016 Mar;9(3):e003283. doi: 10.1161/CIRCEP.115.003283

Table 4. Univariate Predictors of Mortality After Generator Replacement.

Risk Factor HR 95% CI P Value
Age (per increment of 1 y) 1.05 1.03–1.07 <0.001
Hypertension 2.58 1.37–4.84 0.003
Atrial fibrillation 2.90 1.86–4.51 <0.001
Peripheral vascular disease 1.73 1.06–2.82 0.029
Stroke or transient ischemic attack 2.26 1.39–3.65 0.001
NYHA functional class (per increase in
NYHA class of 1)		 1.66 1.21–2.28 0.002
QRS duration (per increment of 10 ms) 1.08 1.03–1.13 0.003
Hemoglobin (per decrement of 1 g/dL) 1.32 1.17–1.49 <0.001
Estimated glomerular filtration rate
(per decrement of 10 mL/min 1.73 m2)		 1.18 1.08–1.29 <0.001
Blood urea nitrogen (per increment of
10 mg/dL)		 1.23 1.13–1.34 <0.001
Serum sodium (per decrement
of 10 mEq/L)		 1.79 0.94–3.38 0.07
ACE inhibitor/ARB therapy 0.61 0.35–1.07 0.08

ACE/ARB indicates angiotensin-converting enzyme inhibitor/aldosterone receptor blocker; CI, confidence interval; HR, hazard ratio; and NYHA, New York Heart Association.