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Meta-miRNA inhibitory network for breast cancer estimated via Poisson graphical models from miRNA-sequencing data. Level III data from TCGA was processed into tightly correlated clusters, meta-miRNAs, with the driver miRNAs identified for each cluster taken as the set of nodes for our network. The Poisson network reveals major inhibitory relationships between three hub miRNAs, two of which have been previously identified as tumor suppressors in breast cancer.
