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. 2016 Jul 26;12(3):1741–1749. doi: 10.3892/etm.2016.3547

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Copyright: © Chu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Lovastatin protects HUVECs against ox-LDL-induced cytotoxicity. Cells were treated with 20 µg/ml ox-LDL, 0.5 µM lovastatin or a combination of both for 24 h. (A) Cell viability was determined using the cell counting kit-8 assay. (B) Cell apoptosis was assessed by Annexin V and PI staining, followed by flow cytometry. (C) Percentage of apoptotic cells. (D) Protein expression was analyzed by western blotting and band intensities were determined using ImageJ software, following normalization to a control (β-actin). Data are presented as the mean ± standard deviation of three independent experiments. *P<0.05 vs. the control cells; ^#P<0.05 vs. the ox-LDL group. HUVECs, human umbilical vein endothelial cells; ox-LDL, oxidized low-density lipoprotein; PI, propidium iodide.