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. 2016 Jul 25;12(3):1763–1768. doi: 10.3892/ol.2016.4909

Figure 4.

Figure 4.

Inhibitory effect of famitinib alone compared with 5-fluorouracil, cisplatin or paclitaxel alone on in BGC-823 xenografts. Growth curves of (A) xenografts and (B) animal weight treated with famitinib (50 mg/kg) or control (n=5 mice/group, mean ± SD). (C) H&E staining revealed areas of tissue necrosis following famitinib treatment (*) (magnification, ×200). (D) Tumor vascularization was significantly suppressed by famitinib according to CD34 expression (magnification, ×200). (E) Upon treatment, tumor xenografts were isolated and photographed. (F) Tumor volumes from each group were measured (n=5 mice/group, mean ± SD). CD, cluster of differentiation; 5-FU, 5-fluorouracil; DDP, cisplatin; PTX, paclitaxel; SD, standard deviation.