Figure 1.

Histogram depicting alteration of the mRNA transcripts of Dickkopf-1 in the metastatic bone lesions and multiple myeloma. The normalized mRNA expression was estimated from the different transcripts from the standard curves. The primary tumors had no evidence of radiologic lesions but were biopsied because of persistent complaints of bone pain. The differences in the means between the groups were statistically significant when compared by analyses of variance. mRNA, messenger ribonucleic acid, #Metastatic bone lesion versus control (P <0.01); ∗metastatic bone lesion versus its corresponding primary tumor (P <0.01).