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. 2016 Jul 11;12(3):2055–2061. doi: 10.3892/ol.2016.4838

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Figure 1. — Silencing of CXCR4 inhibits invasion and migration and promotes apoptosis in TSCCA cells. (A-C) si-CXCR4 inhibited the expression of CXCR4 mRNA and protein. (D) A wound healing assay was performed to investigate TSCCA migration following transfection with si-CXCR4. si-CXCR4 significantly suppressed cells migration. (E) A Transwell assay was performed to compare the invasive capacities of TSCCA cells. si-CXCR4 inhibited cell invasion in vitro (magnification, ×400). (F) si-CXCR4 mediated an increase in the apoptosis of TSCCA cells. *P<0.05 and **P<0.01 vs. control. CXCR4, C-X-C chemokine receptor type 4; si-CXCR4, small interfering RNA to CXCR4; TSCCA, tongue squamous cell carcinoma; control, blank control group; NC, negative control small interfering RNA group.