Table III.
Identified saliva proteins over- and downregulated in the cases available.
| Protein name | NCBI number | MW, kDa | Sequence coverage, %a | Sequence | Scoreb | P-value (cut-off 0.05) | Upregulated/downregulated |
|---|---|---|---|---|---|---|---|
| FBR vs. healthy control | |||||||
| Actin, cytoplasmic 2 | gi|578831328 | 51 | 6 (27/468) | VQTLEAWVIHGGREDSR | 53.2 | <0.00010 | Control high, FBR low |
| α-2-macroglobulin | gi|578822814 | 167 | 32 (487/1512) | AFQPFFVELTMPYSVIR | 53.2 | <0.00010 | Control high, FBR low |
| IDC vs. healthy control | |||||||
| α-2-macroglobulin | gi|578822814 | 167 | 32 (487/1512) | LLLQQVSLPELPGEYSMK | 145.2 | <0.00010 | Control high, IDC low |
| Ceruloplasmin | gi|578807061 | 125 | 19 (205/1090) | EYTDASFTNRK | 80.4 | <0.00010 | Control high, IDC low |
| Chain A, quaternary R structure in complex with a thiol-containing compound | gi|685425643 | 15 | 31 (44/141) | LRVDPVNFK | 43.0 | 0.00010 | Control high, IDC low |
| Chain B, quaternary R co-liganded hemoglobin structure in complex with a thiol-containing compound | gi|685425644 | 16 | 47 (68/146) | FFESFGDLSTPDAVMGNPK | 54.1 | 0.00070 | Control high, IDC low |
| Complement factor H | gi|578800846 | 133 | 8 (92/1173) | EIMENYNIALR | 64.2 | <0.00010 | Control high, IDC low |
| Leukocyte elastase inhibitor (fold-change 4.0)c | gi|578811455 | 43 | 16 (59/379) | EATTNAPFR | 56.3 | 0.00076 | Control low, IDC high |
| FBR vs. IDC | |||||||
| α-enolase (fold-change 3.4)c | gi|578798587 | 47 | 23 (101/434) | AAVPSGASTGIYEALELR | 117.4 | <0.00010 | FBR low, IDC high |
| α-2-macroglobulin | gi|578822814 | 167 | 2 (29/1512) | LLLQQVSLPELPGEYSMK | 72.5 | <0.00010 | FBR high, IDC low |
| Ceruloplasmin | gi|578807061 | 125 | 14 (152/1090) | EYTDASFTNRK | 70.1 | <0.00010 | FBR high, IDC low |
a
Peptides identified by the total protein
b
Ion mascot score ≥40
c
Proteins with values above the fold-change cut-off of 1.5. MW, molecular weight; FBR, fibroadenoma; IDC, infiltrative ductal carcinoma.