Table IV.

Identified plasma proteins over- and downregulated in the cases available.

Protein name	NCBI number	MW, kDa	Sequence coverage, %a	Sequence	Scoreb	P-value (cut-off 0.05)	Upregulated/downregulated
FBR vs. healthy control
α-2-macroglobulin (fold-change 2.3)c	gi|578822814	167	2 (25/1512)	AIGYLNTGYQR	57.8	<0.00010	Control low, FBR high
Chain B, quaternary R co-liganded hemoglobin structure in complex with a thiol-containing compound (fold-change 3.7)c	gi|685425644	16	42 (62/146)	FFESFGDLSTPDAVMGNPK	46.1	<0.00010	Control low, FBR high
Ceruloplasmin (fold-change 4.4)c	gi|578807061	125	25 (269/1090)	KGSLHANGR	45.7	<0.00010	Control low, FBR high
Haptoglobin	gi|530423845	167	2 (25/1512)	HYEGSTVPEKK	57.8	<0.00010	Control low, FBR high
Hornerin	gi|578800920	213	3 (57/2146)	GEQHGSSSGSSSSYGQHGSGSR	73.3	0.00430	Control low, FBR high
Vitamin D-binding protein	gi|578809023	48	12 (52/425)	KFPSGTFEQVSQLVK	106.8	0.00022	Control high, FBR low
IDC vs. healthy control
α-2-macroglobulin (fold-change 13)c	gi|578822814	167	6 (95/1512)	AIGYLNTGYQR	93.7	<0.00010	Control low, IDC high
Chain B, qauternary R co-liganded hemoglobin structure in complex with a thiol-containing compound (fold-change 2.1)c	gi|685425644	16	31 (45/146)	VNVDEVGGEALGR	54.5	0.00013	Control low, IDC high
Vitamin D-binding protein	gi|578809023	48	6 (24/425)	LAQKVPTADLEDVLPLA EDITNILSK	106.8	<0.00010	Control high, IDC low
FBR vs. IDC
α-2-macroglobulin (fold-change 3.5)c	gi|578822814	167	6 (95/1512)	AIGYLNTGYQR	93.7	0.00380	FBR low, IDC high
Ceruloplasmin	gi|578807061	125	1 (13/1090)	GAYPLSIEPIGVR	45.7	<0.00010	FBR high, MC low
Hornerin	gi|578800920	213	3 (57/2146)	GEQHGSSSGSSSSYGQHGSGSR	73.3	0.00160	FBR high, MC low

^aPeptides identified by the total protein

^bIon mascot score ≥40

^cProteins with values above the fold-change cut-off of 1.5. MW, molecular weight; FBR, fibroadenoma; IDC, infiltrative ductal carcinoma.