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. 2016 Feb 18;95(7):e2243. doi: 10.1097/MD.0000000000002243

FIGURE 1.

FIGURE 1

(A) MICs distribution of KPC Escherichia coli by VITEK-2 system. Values in brackets refer to MIC determination by broth macrodilution method (BMD). (B) Time–kill studies for ertapenem, meropenem, and ertapenem plus meropenem against KPC E coli. The horizontal line represents a reduction of 3 log10 CFU/mL compared with the initial bacterial count. Bactericidal activity was defined as a ≥3-log10 CFU/mL reduction of the initial bacterial count at each time point whereas synergy was defined as a ≥2-log10 decrease in CFU/mL between the combinations and its most active constituent after 24 h. ERT = ertapenem, GC = growth control, KPC = Klebsiella pneumoniae carbapenemase, MEM = meropenem, MIC = minimal inhibitory concentration, TMP/SMX = trimethoprim/sulfamethoxazole.