FIGURE 2.

The downstream targets of F-box/WD repeat-containing protein 7 (Fbxw7) in different human solid tumor types. Fbxw7 coordinates the ubiquitin-dependent proteolysis of many key oncoproteins, and identifying critical Fbxw7 substrates are important for understanding tumorigenesis and discovering therapeutic targets. As shown above, in different human solid tumor types, the downstream targets of Fbxw7 are also different, which largely provide a new clue for the development of therapeutic targets in our fight against different cancer.