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Adult mice with a targeted disruption of miR-17-92 show testis atrophy and male germ cell loss. A, Testes from control (left) and KO (right) male mice. B, Testis weight in control and KO mice (n > 5). Other details as in (F). C, Testis histological phenotype of adult control and KO mice. D, Statistical analysis of empty seminiferous tubules detected by H&E staining. D1, D7, D14, D21, and D28 represent the 1st, 7th, 14th, 21st, and 28th days after the last tamoxifen injection.
