FIGURE 13.

Trial sequential analysis of 9 trials reporting requirement of dialysis. The required information size (RIS) of 170,510 is based on an anticipated intervention effect of 11% relative risk increase, a control event proportion estimated from the cumulated incidence of requirement of dialysis in the sodium chloride arm, and a diversity of 0%, α of 5%, power of 80%. RIS is far from reached and none of the boundaries for benefit or harm has been crossed, leaving the meta-analysis inconclusive of an 11% relative risk increase. The trial sequential analysis adjusted 95% confidence interval for a relative risk of 1.10 is 0.61 to 1.99.