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Forest plot of tailored therapy versus empiric treatments on eradication rates by intention-to-treat (ITT) analysis in (A) and by preprotocol (PP) analysis in (B). A random-effect model was used. Significant heterogeneity was shown among the studies in both ITT (I2 = 57.1%, P = 0.003) and PP (I2 = 73.2%, P = 0.000).
