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. 2016 Sep;90(3):265–274. doi: 10.1124/mol.116.104174

Fig. 2.

Fig. 2.

mRNA levels of neurodevelopment-related genes in brains of hUGT1 mice treated with phenytoin during the perinatal period. PTU was given to dams from gestation day 14 to postnatal day 14. (A) The mRNA levels of synapsin I and synaptophysin in the hippocampus were measured in control (closed column, n = 3) and PTU-treated mice (shaded column, n = 3). Dams and their pups were treated with phenytoin daily from gestation day 12, 13, or 14 to postnatal day 0 (p.o.) and from postnatal day 1 to day 14 (s.c.). (B) On postnatal day 14, mRNA levels of synapsin I and synaptophysin in the hippocampus were determined in control (closed column, n = 3) and phenytoin (PHT)-treated mice (open column, n = 3). Error bars show the S.D. of biologic replicates. *P < 0.05; **P < 0.01; ***P < 0.001 compared with control.