TABLE 1.
Echo and hemodynamic data from dogs with AF
MR grade based on Doppler flow criteria with 1 = mild, 2 = moderate, 3 = severe, and 4 = torrential.
| Sinus Rhythm Control (n = 5) | Sustained AF + Vehicle Infusion (n = 5) | Sustained AF + CI-994–Treated (n = 5) | |
|---|---|---|---|
| LA EDL axis (cm) | 2.8 ± 0.30†,‡ | 3.6 ± 0.55* | 3.7 ± 0.49* |
| LA volume (ml) | 18.0 ± 1.3†,‡ | 30.2 ± 2.5* | 33.7 ± 5.3* |
| LV diastolic size (cm) | 4.4 ± 0.32 | 4.7 ± 0.38 | 4.8 ± 0.40 |
| MR grade | 0.4 ± 0.54†,‡ | 2.3 ± 0.5*,† | 2.8 ± 1.1*,‡ |
| LVEF (%) | 62.0 ± 2.8 | 58.5 ± 1.1 | 57.4 ± 3.1 |
| Heart rate (bpm) | 93.8 ± 18.6†,‡ | 156.3 ± 36.6* | 165.6 ± 18.8* |
| Coronary flow (ml/min) | 60.8 ± 7.5 | 53.4 ± 5.8 | 55.2 ± 8.8 |
| dP/dt max. (mm Hg/s) | 3209 ± 140†,‡ | 2149 ± 318* | 2083 ± 308* |
| LV EDP (mm Hg) | 5.1 ± 1.3†,‡ | 9.2 ± 1.5* | 10.1 ± 1.8* |
| LV ESP (mm Hg) | 133.1 ± 11.0 | 119.9 ± 10.9 | 121 ± 16.5 |
LA, left atrium; EDL, end-diastolic long; EDP, end-diastolic pressure; ESP, end-systolic pressure.
*
P < 0.05 versus control;
†
P < 0.05 versus CI-994;
‡
P < 0.05 versus tachypacing.