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. 2016 Sep;358(3):492–501. doi: 10.1124/jpet.116.234443

Fig. 1.

Fig. 1.

Effect of intrathecal orexin-A at (A) subthreshold bolus (100 pmol)/intermittent (10 pmol × 10) and (B) suprathreshold bolus (20 nmol)/intermittent (2 nmol × 10) doses in a urethane-anesthetized rat on (from the top) HR (beats per minute), MAP (mm Hg), and sSNA (µV). Time of administration of intrathecal orexin-A (both single and intermittent) are indicated by the arrow(s). Note that intermittent subthreshold (10 pmol) orexin-A causes the generation of sympathetic long-term facilitation.