Fig. 2.
Role of excipient and compound concentration on brain and plasma levels in 3-day feeding studies. Six- to 11-week old female mice were dosed for 3 days with compounds at the indicated concentrations, using either 0.5% CMC (closed symbols) or 0.125% PEG400 (open symbols) as the excipient. Levels of compound in the brain (blue) and plasma (red) were determined by extraction of tissue with methanol. Each point represents the mean and S.D. of three mice. The EC50 value in ScN2a-cl3 cells is shown as a dotted line for each compound.