TABLE 4.

Pharmacokinetic parameters of aryl amides after oral gavage at 10 mg/kg. Two female FVB mice (9–20 weeks old) were collected per time point; maximum brain concentration (C_max) reported as mean ± S.D.

	Tissue	Cmax	tmax	AUClast
		μM	h	μM/h
1a	Brain	2.52 ± 0.27	2	7.48
	Plasma	0.27 ± 0.01	2	0.97
3	Brain	0.36 ± 0.24	0.25	0.79
4	Brain	1.34 ± 0.36	0.5	0.18
5	Brain	0.19 ± 0.04	0.25	0.18
6	Brain	0.07 ± 0.01	0.25	0.03
7	Brain	0.95 ± 0.20	0.25	2.45
8	Brain	3.59b	0.25	5.60
14	Brain	2.59 ± 0.72	2	16.35
	Plasma	0.34 ± 0.16	0.5	1.15
35	Brain	0.94 ± 0.11	0.5	2.18
37	Brain	5.75 ± 1.34	2	23.97
	Plasma	0.50 ± 0.05	0.5	2.18
38	Brain	0.45 ± 0.15	0.5	0.59
41	Brain	2.49 ± 2.03	2	7.81
	Plasma	0.98 ± 0.01	2	3.65
42	Brain	0.23 ± 0.24	0.5	0.60
43	Brain	0.29 ± 0.03	0.5	1.14
44	Brain	0.52 ± 0.02	2	1.67

^aIncludes data previously reported (Li et al., 2013a).

^bSecond mouse died before collection.