TABLE 5.

Efficacy of aryl amides in prion-infected mice. Four to eight 7- to 10-week old female mice were intracerebrally inoculated with RML or sCJD(MM1) prions, and dosing was started the following day.

Line	Inoculum	Compound	Dose	Excipient	Mean Incubation Period ± S.E.M.	n/n0	Survival Index ± S.E.M.
			mg/kg daily		Per day
FVB	RML	None		CMC	115 ± 2a	4/4	100
		1	200	CMC	Toxic
		1	25	CMC	213 ± 3	4/4	181 ± 3
Tg4053	RML	None		PEG400	51 ± 3b	8/8	100
		14	200	PEG400	112 ± 4	8/8	220 ± 15
		37	200	PEG400	119 ± 3	8/8	233 ± 15
		41	200	PEG400	116 ± 4	8/8	227 ± 16
Tg1014	sCJD(MM1)	None		PEG400	78 ± 1b	7/7	100
		1	25	CMC	76 ± 2	4/4	97 ± 3
		14	200	CMC	74 ± 0	4/4	95 ± 1
		37	200	PEG400	76 ± 1	8/8	97 ± 2
		41	200	CMC	76 ± 2	4/4	97 ± 3

n, number of ill mice; n₀, number of inoculated mice.

^aData previously reported (Giles et al., 2015).

^bData previously reported (Berry et al., 2013).