FIGURE 4.

Course of serum bicarbonates (diamonds) and lactates (circles) on the left y-axis and creatinine (x markers) on the right y-axis over the first 6 days of admission. TMP/SMX was started on admission (day 0) and stopped at day 4. Scales are different for the sake of legibility. While serum bicarbonates was normal on admission, a severe metabolic acidosis developed at day 3, concomitant with an increased lactates. After TMP/SMX cessation, serum bicarbonates and lactates levels normalized within 24 hours.