Table I.

Examples of pharmacogenomic tests with associated CPT codes for identification and documentation.

CPT Code	Test	Description of Test
81225	CYP2C19 genotyping	Detects genetic variants of CYP2C19 associated with variable drug metabolism
81226	CYP2D6 genotyping	Detects genetic variants of CYP2D6 associated with variable drug metabolism
81227	CYP2C9 genotyping	Detects genetic variants of CYP2C9 associated with variable drug metabolism
81355	VKORC1 testing	Detects genetic variants of VKORC1 associated with warfarin therapy
81350	UGT1A1 genotyping	Detects genetic variants of UGT1A1 associated with irinotecan toxicity
84431	11-dehydro thromboxane B2	Measures 11-dehydro thromboxane B2 in urine to determine aspirin resistance
81381	HLA B*57:01	Detects the HLA B*57:01 allele associated with abacavir toxicity
82955	G6PD quantitative	Measures glucose-6-phosphate dehydrogenase activity
81210	BRAF mutation testing	Detects mutations in BRAF associated with BRAF inhibitor therapy
81275	KRAS mutation testing	Detects mutations in KRAS associated with KRAS inhibitor therapy
88360	HER2 expression	Detects the expression of HER2 to guide therapy with HER2 inhibitors
81235	EGFR mutation testing	Detects mutations in EGFR associated with EGFR inhibitor therapy
81220	CFTR profile	Detects mutations in CFTR, which is necessary prior to therapy with ivacaftor
87999	HIV-1 tropism testing	Determines HIV tropism for chemokine receptor 5 [CCR5], and/or chemokine receptor 4 [CXCR4] to guide therapy with receptor antagonists
81287	MGMT gene methylation	Determines MGMT methylation status to guide therapy with alkylating agents

Note: some tests may be components of multi-test panels offered by various companies.