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The mechanism of IL-6 Ab in hepcidin suppression. IL-6-provoked proinflammation effects activate Hamp expression through the Stat3 signaling. Blocking IL-6-activated Stat3 signaling would be an optimal strategy to reduce hepcidin level under inflammation. Tocilizumab is a humanized anti-IL-6R antibody, and it works to inactivate the phosphorylation of Stat3. IL = interleukin.
