Table 2.
Results of DDFPe treatment prior to tPA delivery at 9 h
| Group | Sex | BW (kg) | Embolic site of occlusion | NAS | Time at sacrifice (h)a | Infarct volume (%) | Visible hemorrhage |
|---|---|---|---|---|---|---|---|
| Control | M | 3.6 | MCA/ACA | 18 | 12 | 21.89 | Yes |
| Control | M | 3.7 | MCA | 17 | 4 | 9.15 | No |
| Control | F | 3.4 | MCA | 18 | 7 | 5.61 | No |
| Control | F | 3.4 | MCA/ACA | 1 | 24 | 4.28 | No |
| Control | F | 4.2 | MCA | 18 | 9 | 4.5 | No |
| tPA 9 h | F | 4 | MCA | 0 | 24 | 2.1 | No |
| tPA 9 h | M | 4.5 | MCA/ACA | 0 | 24 | 1.06 | No |
| tPA 9 h | F | 4.4 | MCA | 2 | 24 | 2.13 | Yes |
| tPA 9 h | F | 4.5 | MCA | 2 | 24 | 1.91 | Yes |
| tPA 9 h | F | 4.2 | MCA | 9 | 24 | 2.32 | Yes |
| tPA 9 h | M | 4.2 | MCA | 9 | 24 | 2.46 | Yes |
| tPA 9 h | F | 4.7 | MCA | 0 | 24 | 2.67 | Yes |
| tPA 9 h | F | 4.4 | MCA | 9 | 24 | 3.23 | Yes |
| tPA 9 h | F | 4.4 | MCA | 15 | 9 | 2.33 | Yes |
| tPA 9 h | F | 4.4 | MCA | 14 | 5 | 1.76 | No |
| tPA 9 h | F | 3.9 | MCA | 18 | 12 | 13.16 | Yes |
| DDFPe + PA 9 h | M | 4.4 | MCA | 0 | 24 | 0.28 | No |
| DDFPe + PA 9 h | M | 4 | MCA | 0 | 24 | 0.52 | No |
| DDFPe + tPA 9 h | M | 4.5 | MCA | 0 | 24 | 0.99 | No |
| DDFPe + tPA 9 h | F | 4.2 | MCA | 0 | 24 | 0 | No |
| DDFPe + tPA 9 h | M | 4.4 | MCA | 0 | 24 | 1.92 | No |
| DDFPe + tPA 9 h | M | 3.9 | MCA/ACA | 0 | 24 | 0.28 | Yes |
| DDFPe + tPA 9 h | M | 3.8 | MCA/ACA | 0 | 24 | 1.62 | Yes |
a
Sacrifice was scheduled at 24 h unless early collections were due to severe symptoms