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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 Nov 6;98:19–34. doi: 10.1016/j.addr.2015.10.022

Fig. 13.

Fig. 13

Schematic design of enzyme-responsive graphene oxide-based sequential delivery system. The TRAIL is conjugated on the graphene oxide through a furin-cleavable peptide linker and Dox was loaded on the graphene via π–π stacking interaction. After accumulation at tumor site, the overexpressed furin will cleave the peptide linker and promote the exposition of TRAIL toward death receptors. The Dox-loaded graphene oxide nanosheet will be internalized and Dox will release and accumulate at nuclei with the assistance of acidity of lysosome. Reprinted with permission from [190].